Volume 32, Issue 2 (8-2026)
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Zhouli Z, Donyaei A, Saeedi M. The effect of endurance training on clinical symptoms and nerve conduction velocity in elderly women with peripheral diabetic neuropathy. H 2026; 32 (2) :159-173
URL: http://hayat.tums.ac.ir/article-1-5837-en.html
URL: http://hayat.tums.ac.ir/article-1-5837-en.html
1- Dept. of Physical Education and Sports Sciences, School of Physical Education, Shahrood University of Technology, Shahrood, Iran
2- Dept. of Physical Education and Sports Sciences, School of Physical Education, Shahrood University of Technology, Shahrood, Iran ,Adelldonyai@yahoo.com
3- Dept. of Neurology, School of Medicine, Shahrood University of Medical Sciences, Shahrood, Iran
2- Dept. of Physical Education and Sports Sciences, School of Physical Education, Shahrood University of Technology, Shahrood, Iran ,
3- Dept. of Neurology, School of Medicine, Shahrood University of Medical Sciences, Shahrood, Iran
Abstract: (380 Views)
Background & Aim: Peripheral diabetic neuropathy is one of the most common complications of diabetes in the elderly and requires management interventions. This study aimed to determine the effect of endurance training on clinical symptoms and nerve conduction velocity in elderly women with type 2 diabetes and peripheral diabetic neuropathy.
Methods & Materials: This quasi-experimental study was conducted with the participation of 25 elderly women with peripheral diabetic neuropathy who referred to the Diabetes Association of Shahroud city from May to August 2023. The subjects were randomly divided into intervention (12 subjects) and control (13 subjects) groups. The intervention group performed 12 weeks of aerobic training on a treadmill (three sessions per week, intensity of 50-70% of heart rate reserve, 20-35 minutes per session); the control group received no training intervention and only continued their usual diabetes treatment. Before and after the intervention, nerve conduction was assessed using an EMG/NCV device (Viking Quest, USA), and blood sampling was also performed. Additionally, neuropathy symptoms were evaluated using the Michigan Neuropathy Questionnaire. Data were analyzed using multivariate analysis of covariance with SPSS version 26.
Results: In the intervention group compared to the control group, an increase in neurotrophin-3 (P=0.017) and peroneal nerve conduction velocity (P=0.017) was observed. Insulin resistance (P=0.017) and blood glucose (P=0.019) also significantly improved. However, changes in peroneal nerve amplitude, as well as conduction velocity and amplitude of the sural and tibial nerves, were not significant (P>0.05).
Conclusion: Endurance training can increase some nerve conduction velocity parameters in elderly women with peripheral diabetic neuropathy, and one of the reasons is probably changes in metabolic indices and increased neurotrophin-3.
Methods & Materials: This quasi-experimental study was conducted with the participation of 25 elderly women with peripheral diabetic neuropathy who referred to the Diabetes Association of Shahroud city from May to August 2023. The subjects were randomly divided into intervention (12 subjects) and control (13 subjects) groups. The intervention group performed 12 weeks of aerobic training on a treadmill (three sessions per week, intensity of 50-70% of heart rate reserve, 20-35 minutes per session); the control group received no training intervention and only continued their usual diabetes treatment. Before and after the intervention, nerve conduction was assessed using an EMG/NCV device (Viking Quest, USA), and blood sampling was also performed. Additionally, neuropathy symptoms were evaluated using the Michigan Neuropathy Questionnaire. Data were analyzed using multivariate analysis of covariance with SPSS version 26.
Results: In the intervention group compared to the control group, an increase in neurotrophin-3 (P=0.017) and peroneal nerve conduction velocity (P=0.017) was observed. Insulin resistance (P=0.017) and blood glucose (P=0.019) also significantly improved. However, changes in peroneal nerve amplitude, as well as conduction velocity and amplitude of the sural and tibial nerves, were not significant (P>0.05).
Conclusion: Endurance training can increase some nerve conduction velocity parameters in elderly women with peripheral diabetic neuropathy, and one of the reasons is probably changes in metabolic indices and increased neurotrophin-3.
Type of Study: Research |
Subject:
Nursing Care
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