Volume 11, Issue 2 And 1 (5 2005)                   Back to this Issue | Back to browse issues page

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Khakbazan Z, Alishirzad A, Mirnateghie A, Babaei G, khakbazan M. Effect of magnesium sulfate on bleeding time in pregnancy. Hayat. 2005; 11 (2 and 1) :63-69
URL: http://hayat.tums.ac.ir/article-1-239-en.html
Abstract:   (11596 Views)

Introduction: According to some studies, pharmacological concentrations of Mg2+ have anti-thrombotic effects and interfere with platelet aggregation in vitro and in vivo.

Materials and Methods: The study group consisted of 50 pregnant women who required magnesium sulfate for mild pre-eclampsia or preterm labor. In all patients, a platelet count, magnesium level, bleeding time and mean arterial pressure were obtained before and 2 hours after magnesium sulfate infusion. Magnesium sulfate was started with a 6 gr intravenous bolus, followed by 2 gr/hr infusion. Bleeding time was measured by Duke method. Data were analyzed with Mann Whitney U and Wilcoxon rank tests.

Results: Thirty one patients (62%) received magnesium sulfate for preterm labor and 19 (38%) for mild pre-eclampsia. Analysis of the entire study group revealed a rise in the magnesium level (p<0.0001), a lowering of the mean arterial pressure (p<0.0001) and no significant difference of the bleeding time and platelet count. Comparison of platelet count, magnesium level and bleeding time before and 2 hours after magnesium sulfate infusion revealed no significant difference in two groups.

Conclusion: According to this study, magnesium sulfate with usual dosage has no effect on bleeding time in pregnancy.

Keywords: bleeding time
Full-Text [PDF 158 kb]   (2791 Downloads)    
Type of Study: Research | Subject: Nursing Care
Published: 2013/08/11 | ePublished: 2013/08/11

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